Philip Kern, M.D. is a Professor of Medicine at UAMS, Associate Chief of Staff for Research at the John L. McClellan Memorial Veterans Hospital, and GCRC Associate Program Director. Dr. Kern has done salient research in the basic and clinical mechanisms of obesity and insulin resistance. He is also interested in diabetes and lipid metabolism.
Dr. Kern directs the UAMS Medical Center Weight Control Program – a highly successful, comprehensive, medically supervised, outpatient service that helps each patient reach and then maintain his or her ideal body weight.
Kern PA, Ong JM, Saffari B, Carty J. The effects of weight loss on the expression of adipose tissue lipoprotein lipase in very obese humans. N. Engl. J. Med., 1990. 322:1053-1059.
Maffei M, Halaas J, Ravussin E, Pratley RE, Kim S, Lallone R, Ranganathan S, Kern PA, Friedman JM. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight reduced subjects. Nature Medicine, 1995. 1:1155-1161.
Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB. The expression of tumor necrosis factor in human adipose tissue: regulation by weight loss, and relationship to lipoprotein lipase. J. Clin. Invest. 1995. 95:2111-2119.
Kern PA, Simsolo RB, Fournier M. Effect of weight loss on muscle fiber type, fiber size, capillarity, and succinate dehydrogenase activity in humans. J. Clin. Endocrinol. Metab., 1999. 84:4185-4190.
Kern PA, Ranganathan S, Li C, Wood L, and Ranganathan G. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity–associated insulin resistance. Am. J. Physiol. Endocrinol Metab., 2001. 280:E745-E751.
Ranganathan G, Phan D, Pokrovskaya ID, McEwen JE, Li C, Kern PA. The translational regulation of lipoprotein lipase by epinephrine involves an RNA binding complex including the catalytic subunit of protein kinase A. J. Biol. Chem. 2002. 277:43281-43287.
Kern PA, Di Gregorio G, Lu T, Rassouli N, Ranganathan G. 2003. Adiponectin expression from human adipose tissue: relationship to obesity, insulin resistance and TNFá expression. Diabetes. 52:1770-1785.
Rasouli N, Raue U, Miles LM, Lu T, Di Gregorio GB, Elbein SC, Kern PA. 2005. Pioglitazone improves insulin sensitivity through a reduction in muscle lipid and a redistribution of lipid into adipose tissue Am. J. Physiol. Endo. Metab. 288:E930-E934.
Di Gregorio GB, Yao-Borengasser A, Rasouli N, Varma V, Lu T, Miles LM, Ranganathan G, Peterson CA, McGehee RE, Kern PA. 2005. The expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissue: Association with cytokine expression, insulin resistance, and reduction by pioglitazone. Diabetes. 54:2305-13.
