Stavros Manolagas, M.D., Ph.D. is Chief, Section of Endocrinology and Metabolism; Director, Division of Endocrinology/Metabolism; Director, Center for Osteoporosis and Metabolic Bone Diseases; and Professor of Medicine at UAMS. Dr. Manolagas’ clinical interests include metabolic bone disorders, diseases of the parathyroid glands and other calcium disorders, osteoporosis, hormone replacement and women’s health.

His research interests include the interplay among hormones, cytokines, the hematopoietic/immune system and bone; cellular and molecular mechanisms of the pathogenesis of osteoporosis due to estrogen or androgen deficiency, old age, and glucocorticoid excess; and mechanisms of steroid hormone receptor action. Metabolic Bone Diseases; and Professor of Medicine at UAMS. Dr. Manolagas’ clinical interests include metabolic bone disorders, diseases of the parathyroid glands and other calcium disorders, osteoporosis, hormone replacement and women’s health.

Selected Publications:

Manolagas SC. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocrine Reviews, 2000. 21:115-137.

Kousteni S, Bellido T, Plotkin LI, O’Brien CA, Bodenner DL, Han L, Han K, DiGregorio GB,  Katzenellenbogen JA, Katzenellenbogen BS, Roberson PK, Weinstein RS, Jilka RL, Manolagas SC.  Non-Genotropic, sex non-specific signaling through the estrogen or androgen receptors: Dissociation from transcriptional activity.  Cell, 2001. 104:719-730.

Di Gregorio GB, Yamamoto M, Abe E, Roberson P, Manolagas SC, Jilka RL.  Attenuation of the self-renewal of transit amplifying osteoblast progenitors in the murine bone marrow by 17b-estradiol. J Clin Invest, 2001. 107:803-812.

Manolagas SC and Kousteni S.  Perspective: Non-reproductive sites of action of reproductive hormones. Endocrinology, 2001. 142:2200-2204.

Kousteni S, Chen JR, Bellido T, Han L, Ali AA, O’Brien CA, Plotkin L, Qiang F, Mancino AT, Wen Y, Vertino AM, Powers CC, Stewart SA, Ebert R,Parfitt AM, Weinstein RS, Jilka RL, Manolagas SC. Reversal of bone loss in mice by nongenotropic signaling of sex steriods. Science, 2002. 298:843-846.

Kousteni S, Han L, Chen JR, Almeida M, Plotkin LI, Bellido T and Manolagas SC. Kinase-mediated regulation of common transcription factors accounts for the bone protective effects of sex steroids. J Clin Invest, 2003. 111:1651-1664.